Integrin signaling is integral to regeneration.
作者： Michele L. Lemons , Maureen L. Condic
DOI: 10.1016/J.EXPNEUROL.2007.05.027
关键词:
摘要: The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute regeneration failure. In this review, we focus on impact regeneration, in particular integrin receptors their downstream signaling pathways. We discuss studies address integrins pathways growth cone guidance motility how lessons learned from these apply vivo.
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Maureen L. Condic, Adult Neuronal Regeneration Induced by Transgenic Integrin Expression The Journal of Neuroscience. ,vol. 21, pp. 4782- 4788 ,(2001) , 10.1523/JNEUROSCI.21-13-04782.2001
Alyson E. Fournier, Robert G. Kalb, Stephen M. Strittmatter, Rho GTPases and axonal growth cone collapse. Methods in Enzymology. ,vol. 325, pp. 473- 482 ,(2000) , 10.1016/S0076-6879(00)25467-0
Richard A. Asher, Daniel A. Morgenstern, Lawrence D.F. Moon, James W. Fawcett, Chondroitin sulphate proteoglycans: inhibitory components of the glial scar Progress in Brain Research. ,vol. 132, pp. 611- 619 ,(2001) , 10.1016/S0079-6123(01)32106-4
Kathleen L. O'Connor, Arthur M. Mercurio, Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells Journal of Biological Chemistry. ,vol. 276, pp. 47895- 47900 ,(2001) , 10.1074/JBC.M107235200
Mariette G. Vogelezang, ZhiQiang Liu, João B. Relvas, Gennadij Raivich, Steven S. Scherer, Charles ffrench-Constant, α4 Integrin Is Expressed during Peripheral Nerve Regeneration and Enhances Neurite Outgrowth The Journal of Neuroscience. ,vol. 21, pp. 6732- 6744 ,(2001) , 10.1523/JNEUROSCI.21-17-06732.2001
Zhao Jin, Stephen M. Strittmatter, Rac1 Mediates Collapsin-1-Induced Growth Cone Collapse The Journal of Neuroscience. ,vol. 17, pp. 6256- 6263 ,(1997) , 10.1523/JNEUROSCI.17-16-06256.1997
Inger Olsen, Charles ffrench-Constant, Dynamic regulation of integrin activation by intracellular and extracellular signals controls oligodendrocyte morphology BMC Biology. ,vol. 3, pp. 25- 25 ,(2005) , 10.1186/1741-7007-3-25
Thomas B. Kuhn, Michael D. Brown, Christine L. Wilcox, Jonathan A. Raper, James R. Bamburg, Myelin and Collapsin-1 Induce Motor Neuron Growth Cone Collapse through Different Pathways: Inhibition of Collapse by Opposing Mutants of Rac1 The Journal of Neuroscience. ,vol. 19, pp. 1965- 1975 ,(1999) , 10.1523/JNEUROSCI.19-06-01965.1999
Alexander Werner, Michael Willem, Leonard L. Jones, Georg W. Kreutzberg, Ulrike Mayer, Gennadij Raivich, Impaired Axonal Regeneration in α7 Integrin-Deficient Mice The Journal of Neuroscience. ,vol. 20, pp. 1822- 1830 ,(2000) , 10.1523/JNEUROSCI.20-05-01822.2000
Masaki Hiramoto, Yasushi Hiromi, Edward Giniger, Yoshiki Hotta, The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution Nature. ,vol. 406, pp. 886- 889 ,(2000) , 10.1038/35022571