Interactions between tumor cells and microenvironment in breast cancer: A new opportunity for targeted therapy

摘要: Breast cancer remains the leading cause of morbidity and second-leading death in women. Despite efforts to uncover new targeted therapies, a vast number women die due refractory or recurrent breast tumors. Most studies have focused on intrinsic characteristics tumor cells, including altered growth, proliferation, metabolism. However, emerging research suggests that microenvironment can substantially affect relapse rates therapeutic responses. In this review, we discuss interactions between cancer, with regard mutational profiles metabolism could serve as potential targets. We also describe current technologies available study these interactions. (Cancer Sci 2012; 103: 400–407)