Game-Theoretical Modeling of Interviral Conflicts Mediated by Mini-CRISPR Arrays.

摘要: All cellular organisms coevolve with multiple viruses, so that both virus-host and intervirus conflicts are major factors of evolution. Accordingly, hosts evolve multiple, elaborate defense systems viruses respond by evolving means antidefense. Although less thoroughly characterized, several dedicated mechanisms competition have been described as well. Recently, the genomes some bacterial archaeal shown to harbor CRISPR mini-arrays typically contain a single spacer targeting closely related virus. The involvement in an conflict has experimentally demonstrated for pair viruses. We model evolution virus-encoded using game theoretical approach. Analysis reveals equilibria include mutual targeting, unidirectional no cyclic polymorphism, bistability. choice between these evolutionary regimes depends on parameters including coinfection frequency, differential productivity conflicting fitness cost mini-arrays. At high frequencies, becomes version Prisoner's dilemma which defection, i.e., competing is winning strategy.