Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: A Children's Oncology Group study

摘要: An infectious origin for pediatric Hodgkin lymphoma (HL) has long been suspected and Epstein-Barr virus (EBV) implicated in a subset of cases. Increased HL incidence children with congenital acquired immunodeficiencies, consistent associations between autoimmune diseases adult HL, genome-wide association other genetic studies together suggest immune dysregulation is involved lymphomagenesis. Here, healthy control identified by random digit dialing were matched on sex, race/ethnicity, age to cases diagnosed 1989-2003 at 0-14 years Children’s Oncology Group institutions. Parents 517 784 controls completed telephone interviews, including items regarding medical histories. Tumor EBV status was determined 355 Using conditional logistic regression, we calculated odds ratios (ORs) 95% confidence intervals (CIs) risk HL. Cases more likely have had an infection >1 year prior diagnosis (OR=1.69, CI:0.98-2.91); case siblings also (OR=2.04, CI:1.01-4.14). Parental history autoimmunity associated increased EBV+ (OR=2.97, CI:1.34-6.58), while having parent (OR=1.47, CI:1.01-2.14) or sibling (OR=1.62, CI:1.11-2.36) allergy EBV− These results may indicate true infections family allergic conditions that varies tumor status, they be attributable inaccurate recall. In addition employing biomarkers confirm the role immune-modulating future should focus family-based designs.