Risk factors for Hodgkin's disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents.

摘要: A UK population-based case-control study of Hodgkin's disease (HD) in young adults (16-24 years) included 118 cases and 237 controls matched on year birth, gender county residence. The majority (103) the were classified by Epstein-Barr virus (EBV) status (EBV present Reed-Stenberg cells), with 19 being EBV-positive. Analyses using conditional logistic regression are presented subject reports prior infectious (infectious mononucleosis (IM), chicken pox, measles, mumps, pertussis rubella). In these analyses HD compared controls, EBV-positive EBV-negative separately their formal tests differences association EBV applied. history IM was positively associated (odds ratio (OR) = 2.43, 95% confidence interval (CI) 1.10-5.33) (OR 9.16, CI 1.07-78.31) difference between statistically significant (P 0.013). remaining illnesses (combined) negatively HD, (in total series, for > or =2 episodes < =1, OR 0.45, 0.25-0.83). These results support previous evidence that early exposure to infection protects against increases subsequent risk; comparisons new generate hypotheses further study.