Midodrine exacerbates promethazine-induced akathisia
作者： Janice V. Meck , Shang-Jin Shi , Steven H. Platts
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摘要: The study of physiological changes during spaceflight, and the pursuit remedies to counteract those changes, often requires unique research protocols that lead unexpected findings; some with important clinical implications. In our into development treatments detrimental cardiovascular effects we have discovered an drug interaction between promethazine midodrine.
参考文章(6)
Katsunori Nakamura, Tsuyoshi Yokoi, Kazuaki Inoue, Noriaki Shimada, Noriko Ohashi, Toshiyuki Kume, Tetsuya Kamataki, CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. ,vol. 6, pp. 449- 457 ,(1996) , 10.1097/00008571-199610000-00009
Thomas R. E. Barnes, A rating scale for drug-induced akathisia. British Journal of Psychiatry. ,vol. 154, pp. 672- 676 ,(1989) , 10.1192/BJP.154.5.672
Donna McTavish, Karen L. Goa, Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders. Drugs. ,vol. 38, pp. 757- 777 ,(1989) , 10.2165/00003495-198938050-00004
Masayuki Akimoto, Izumi Iida, Hiroki Itoga, Atsunori Miyata, Shizuko Kawahara, Yoshiro Kohno, The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. European Journal of Drug Metabolism and Pharmacokinetics. ,vol. 29, pp. 179- 186 ,(2004) , 10.1007/BF03190595
Frieder K. Kees, H. F. Grobecker, Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers. International Angiology. ,vol. 12, pp. 119- 124 ,(1993)
John W. Dundee, James Moore, William J. Love, Robert M. Nicholl, Richard S.J. Clarke, STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA. VI. THE PHENOTHIAZINE DERIVATIVES. BJA: British Journal of Anaesthesia. ,vol. 37, pp. 332- 353 ,(1965) , 10.1093/BJA/37.5.332