Midodrine. A review of its pharmacological properties and therapeutic use in orthostatic hypotension and secondary hypotensive disorders.

摘要: Midodrine, a peripheral alpha-adrenergic agonist, finds use in the clinical management of patients with orthostatic hypotension or secondary to other conditions drug therapies. Midodrine is almost completely absorbed after oral administration and undergoes enzymatic hydrolysis form its pharmacologically active metabolite, de-glymidodrine. In refractory midodrine increases standing blood pressure improves symptoms orthostatism, such as weakness, syncope, blurred vision fatigue, without any associated cardiac stimulation. Comparative studies have shown be clinically at least effective sympathomimetic agents (norfenefrine, etilefrine, dimetofrine ephedrine) dihydroergotamine this regard. Additionally, appears cause less frequent severe adverse effects alpha-receptor agonism piloerection urinary hesitancy. The most commonly experienced effects--piloerector reactions, gastrointestinal disorders, cardiovascular complaints--are generally mild can controlled by reducing dosage midodrine. Thus, useful currently available options hypotension, represents stepping stone towards optimal therapy.