The role of phenethyl isothiocyanate on bladder cancer ADM resistance reversal and its molecular mechanism.
作者： Kai Tang , Yi Lin , Li‐Ming Li , None
DOI: 10.1002/AR.22677
关键词:
摘要: Adramycin (ADM) resistance is an essential aspect of bladder cancer treatment failure and phenethyl isothiocyanate (PEITC) has been found to exhibit antitumor properties; however, the effect potential mechanism PEITC on ADM reversal not fully clear. The aim this study was explore role in cells underlying molecular mechanisms. In report, we identified human carcinoma T24/ADM cells, including increased drug sensitivity ADM, cell apoptosis rates, intracellular accumulation Rhodamine-123 (Rh-123), expression DNA topoisomerase II (Topo-II), a decreased multidrug gene (MDR1), resistance-associated protein (MRP1), bcl-2 glutathione s transferase π (GST-π).We also that there NF-κB, Survivin, Twist, p-Akt, PTEN p-JNK after for T24/ cells. results indicated might be used as therapeutic strategy through blocking Akt activating MAPK pathway carcinoma.
sci-hub.se 参考文章(32)
B Weyhenmeyer, J H M Prehn, B M Murphy, A C Murphy, Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer. Experimental Oncology. ,vol. 34, pp. 192- ,(2012)
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M. Martelli, Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response Oncotarget. ,vol. 3, pp. 954- 987 ,(2012) , 10.18632/ONCOTARGET.652
Andreas-Claudius Hoffmann, Peter Wild, Christina Leicht, Simone Bertz, Kathleen D. Danenberg, Peter V. Danenberg, Robert Stöhr, Michael Stöckle, Jan Lehmann, Martin Schuler, Arndt Hartmann, MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy Neoplasia. ,vol. 12, pp. 628- 636 ,(2010) , 10.1593/NEO.10402
HAIPING ZHANG, AIHUA SUI, ZHENLI WANG, SHIHAI LIU, RUYONG YAO, Adenovirus-mediated TRAIL expression and downregulation of Bcl-2 expression suppresses non-small cell lung cancer growth in vitro and in vivo International Journal of Molecular Medicine. ,vol. 30, pp. 358- 364 ,(2012) , 10.3892/IJMM.2012.998
R. Koren, V. Kugel, Y. Dekel, Y. Weissman, P.M. Livne, R. Gal, Human DNA topoisomerase-IIα expression as a prognostic factor for transitional cell carcinoma of the urinary bladder BJUI. ,vol. 91, pp. 489- 492 ,(2003) , 10.1046/J.1464-410X.2003.04118.X
Ahmad Al-Azayzih, Fei Gao, Anna Goc, Payaningal R Somanath, None, TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases. Biochemical and Biophysical Research Communications. ,vol. 427, pp. 165- 170 ,(2012) , 10.1016/J.BBRC.2012.09.035
L Li, X H Wei, Y P Pan, H C Li, H Yang, Q H He, Y Pang, Y Shan, F X Xiong, G Z Shao, R L Zhou, LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling. Oncogene. ,vol. 29, pp. 5785- 5795 ,(2010) , 10.1038/ONC.2010.303
Le-Ye He, Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax Oncology Letters. ,vol. 3, pp. 879- 884 ,(2012) , 10.3892/OL.2012.572
Xiang Wu, Qing-hua Zhou, Ke Xu, Are isothiocyanates potential anti-cancer drugs? Acta Pharmacologica Sinica. ,vol. 30, pp. 501- 512 ,(2009) , 10.1038/APS.2009.50
Yun Hee Kang, Na Young Ji, Seung Ro Han, Chung Il Lee, Jae Wha Kim, Young Il Yeom, Young Ho Kim, Ho Kyung Chun, Jong Wan Kim, Jin Woong Chung, Dong Kuk Ahn, Hee Gu Lee, Eun Young Song, ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer. Cellular Signalling. ,vol. 24, pp. 1940- 1949 ,(2012) , 10.1016/J.CELLSIG.2012.06.004