Susceptibility of Candida albicans to peroxidase-catalyzed oxidation products of thiocyanate, iodide and bromide.

摘要: The susceptibility of Candida albicans (ATCC 10231 and wild strains) to hypo(pseudo)halous ions (OSCN-, OBr-, OI-) produced by the lactoperoxidase system was tested. Six strains were isolated from swabs taken mouths children with orthodontic appliances selected on Sabouraud-Chloramphenicol-Actidione agar plates. survival rate blastospores after a 30 min exposure ranged 79 105% in presence 615 microM thiocyanate, 56 88% 345 bromide 0 4% 250 iodide. Results showed that only OI- could exert strong inhibiting effect vitro at physiological concentrations. Nevertheless, activity hypoiodite generating saliva found be under control thiocyanate concentration.