Sodium/iodide-symporter: distribution in different mammals and role in entero-thyroid circulation of iodide.

摘要: The sodium (Na+)/iodide (I-)-symporter (NIS) is abundantly expressed and accumulates iodide in thyroid follicular cells. NIS also found extrathyroidal tissues, particularly gastric mucosa. Controversies exist on the localization of NIS. We have studied presence both peptide messenger RNA (mRNA) digestive tract from different mammals. role enigmatic we aimed to unravel its possible involvement transport. Methods: Distribution expression were using immunocytochemistry situ hybridization. Iodide transport gastrointestinal was measured after oral or intravenous (i.v.) administration 125I rats with without ligation pylorus. Results: All cells rat mouse NIS, whereas a patchy staining noted man, pig guinea-pig. Gastric mucosa surface epithelium all species ductal parotid gland guinea-pig, In parietal endocrine intestines pancreas immunoreactivity but no mRNA found. Studies uptake showed marked circulation into lumen. Conclusions: varies slightly among To establish particular cell type need correlate protein by hybridization emphasized. An entero-thyroidal mediated principally possibly salivary glands suggested. (Less)