Attenuation of injury due to unilateral renal ischemia: delayed effects of contralateral nephrectomy.

摘要: The functional abnormalities associated with unilateral postischemic acute renal failure in the rat, as produced by 60 min of complete artery occlusion, are influenced presence or absence contralateral kidney. When kidney is removed prior to ischemia, reflow blood more complete. To determine whether this maneuver ultimate severity injury and, if so, investigate mechanism which occurred, studies were performed conjointly at Tel-Hashomer, Israel, and Chapel Hill, N.C., uninephrectomized (UNx) sham-operated (Sh) rats. At V from UNx rats was nearly double that found Sh 1 3, 3 5, 24 hr after ischemia. By hr, CCr substantially greater similar nonischemic Differences tubular function also noted. In rats, FENa significantly less TCH2O than corresponding values determined RBF PGCe although both obtained kidneys. RT RPG considerably Microscopic examination revealed widespread epithelial cell necrosis contrast, structures preserved These data indicate substantive differences exist response temporary depend part on result severe reduction preservation structure function.