The Impact of Residual Renal Function on Graft and Patient Survival Rates in Recipients of Preemptive Renal Transplants

摘要: ● Background: Transplantation before the initiation of dialysis is associated with prolonged allograft survival. It unclear if this benefit attributable to greater residual renal function or avoidance exposure. The authors performed an analysis determine whether higher at transplant was increased patient and graft survival rates. Methods: identified individuals who between 1994 June 2000 were > 18 years had undergone a living donor (Tx) as initial form replacement therapy. Pre-Tx 6-month estimated glomerular filtration rates (eGFR) calculated using 4-variable Modification Diet in Renal Disease formula. Survival compared those pre-Tx eGFR >15mL/min less than 15 mL/min, after adjusting for demographic variables, co-morbidities, characteristics. rate then adjusted propensity scores. Results: A total 4,046 patients included. Mean 9.9 mL/min (0.9 57.1 mL/min). There no difference by strata any tested models, even correcting score (hazard ratio, 0.95; 95% confidence interval, 0.69 1.30). correlation post-Tx (r 2 0.005). Conclusion: Recipients preemptive transplants fair equally, regardless which they receive their transplant. relationship eGFR, suggesting that independent level function. These data suggest kidney transplantation should be delayed long possible, provided does not have uremic symptoms, can safely avoided. Am J Kidney Dis 42:1275-1282. © 2003 National Foundation, Inc.