Predictors of Chronic Kidney Disease in Long-Term Survivors of Lung and Heart-Lung Transplantation

摘要: Renal insufficiency is common after non-renal organ transplants. The predictors of long-term renal outcomes are not well established. A total 219 lung and heart-lung transplant recipients surviving more than 6 months transplantation were studied to determine time doubling serum creatinine end-stage kidney disease (ESKD) with death as a competing risk. Median follow-up was 79 (range 9-222 months). Baseline estimated glomerular filtration rate (GFR) 96.3+/-34.5 mL/min/1.73 m2. One hundred twenty-two (55%) doubled their creatinine, 16 (7.3%) progressed ESKD 143 (65%) died. majority who survived >6 years had GFR<60 mL/min at both 1 7 years. Most the loss function occurred in first year post-transplant. Older age transplant, lower GFR month cyclosporine use predicted shorter when handled Based on this prevalence data using decay study endpoints, we offer sample size estimates for prospective, interventional trial that aimed slowing or preventing progression disease.