Former Smoking Is a Risk Factor for Chronic Kidney Disease After Lung Transplantation

摘要: Chronic kidney disease (CKD) is a common complication after lung transplantation (LTx). Smoking risk factor for many diseases, including CKD. cessation >6 months required LTx enlistment. However, the impact of smoking history on CKD development remains unclear. We investigated effect former and mortality LTx. was based glomerular filtration rate (GFR) (I-125-iothalamate measurements). GFR measured before repeatedly One hundred thirty-four patients never smoked 192 previously median 17.5 pack years. At 5 years LTx, overall cumulative incidences CKD-III, CKD-IV death were 68.5%, 16.3% 34.6%, respectively. Compared to smokers, smokers had higher CKD-III (hazard ratio [HR] 95% confidence interval [95% CI] = 1.69 [1.27-2.24]) IV (HR 1.90 [1.11-3.27]), but not 0.99 [0.71-1.38]). Adjustment potential confounders did change results. Thus, despite cessation, remained in recipients. Considering increasing acceptance older recipients with lower baseline renal function an extensive history, our data suggest that problem post-LTx may increase future.