The value of liver-based standardized uptake value and other quantitative 18F-FDG PET-CT parameters in neoadjuvant therapy response in patients with locally advanced rectal cancer: correlation with histopathology.

摘要: AIM We aimed to investigate the value of PET-CT in therapy response and correlation quantitative PET parameters with histopathologic results patients locally advanced rectal cancer (LARC) before after neoadjuvant chemoradiotherapy. also analyzed between Ki-67 glucose transporter 1 (GLUT1). PATIENTS AND METHODS A total 29 diagnosed LARC who had undergone a biopsy 2009 2012 were included our study. Quantitative [standardized uptake (SUV)max-mean, lean body mass SUV(max-mean), tumor/liver SUV, retention index , [INCREMENT]SUV(max)] measured using PET-CT. Tumor regression grade (TRG) was evaluated according Wheeler's classification. Patients considered responders, whereas at grades 2 3 nonresponders. Immunohistochemical staining GLUT1 performed on surgical specimens. The ratios SUV investigated. RESULTS significantly decreased (P < 0.001). Twelve (41%) TRG1, 10 (35%) TRG2, seven (24%) TRG3. cutoff SUV(max) 5.05 discriminate responders nonresponders treatment revealed sensitivity 57%, specificity 73%, negative predictive 65%, positive 67%, accuracy 66%. Using 3.55 for SUV(mean) (standardized measurement 1.2-cm-diameter region interest) sensitivity, specificity, value, 67, 76, 72%, respectively. For 1.95 tumor SUV(mean)/liver SUV(mean), these diagnostic values 73, 78, 82, 76%, found moderate liver-based (r = -0.35, P 0.019) SUV(mean )(r -0.31, 0.036) therapy. moderately correlated Ki-67. CONCLUSION is useful method assessing chemoradiotherapy LARC. most significant parameter ratio.