Noninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: correlation with tumor response to fluorouracil.
作者： M Findlay , H Young , D Cunningham , A Iveson , B Cronin
DOI: 10.1200/JCO.1996.14.3.700
关键词: Rectum 、 Fluorodeoxyglucose 、 Colorectal cancer 、 Medicine 、 Positron emission tomography 、 Fluorouracil 、 Chemotherapy 、 Nuclear medicine 、 Metastasis 、 Standardized uptake value
摘要: PURPOSETo investigate and measure the metabolism of colorectal cancer liver metastases using 18F-fluorodeoxyglucose positron emission tomography (FDG PET), before during first month chemotherapy. The findings were compared with tumor outcome conventionally assessed changes in size.PATIENTS AND METHODSPatients treated fluorouracil (5FU) as a protracted venous infusion (300 mg/m2/d), or without interferon-alpha 2b for two 10-week blocks separated by 2-week break. Before at 1 to 2 4 5 weeks on treatment, FDG PET scans performed. Patients fasted, injected intravenously (50 100 MBq), scanned large-area camera; image data was processed such that regions interest could be identified. results expressed ratio uptake normal (T:L) semiquantitative standardized value (SUV). These measures dim...
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