Decreased Number of Parvalbumin and Cholinergic Interneurons in the Striatum of Individuals with Tourette Syndrome

摘要: Corticobasal ganglia neuronal ensembles bring automatic motor skills into voluntary control and integrate them ongoing behavior. A 5% decrease in caudate (Cd) nucleus volume is the most consistent structural finding brain of patients with Tourette syndrome (TS), but cellular abnormalities that underlie this are unclear. In study density different types interneurons medium spiny neurons (MSNs) striatum was assessed postmortem brains 5 TS subjects as compared normal controls (NC) by unbiased stereological analyses. demonstrated a 50%-60% both parvalbumin (PV)+ choline acetyltransferase (ChAT)+ cholinergic Cd putamen (Pt). Cholinergic were decreased associative sensorimotor regions not limbic striatum, such gradient cells (highest regions, intermediate lowest regions) abolished. No significant difference present densities medium-sized calretinin (CR)+ interneurons, MSNs, total neurons. The selective deficit PV+ striatal may result an impaired cortico/thalamic neuron firing TS.