Process to tetrahydrotriazolopyrazines and intermediates
作者： Jinchu Liu , Jaume Balsells
DOI:
关键词:
摘要: A novel process is provided for the preparation of substituted-5,6,7,8-tetrahydro[1,2,4]-triazolo[4,3-α]pyrazines which are useful in synthesis dipeptidyl peptidase-IV inhibitors treatment Type 2 diabetes. Also intermediates obtained from process.
lens.org 参考文章(4)
Emma R. Parmee, Scott D. Edmondson, Malcolm Maccoss, Ann E. Weber, Jinyou Xu, Dooseop Kim, Michael H. Fisher, Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes ,(2002)
Richard B. Sulsky, Joseph Anthony Tino, William R. Ewing, James J. Li, Guixue Yu, Jun Li, Heterocyclic aromatic compounds useful as growth hormone secretagogues ,(2005)
Gary A. McCort, Jean Claude Pascal, A rapid and efficient synthesis of imidazo [1,2-a] and 1,2,4-triazolo [4,3-a]-piperazine car☐ylic acids. Tetrahedron Letters. ,vol. 33, pp. 4443- 4446 ,(1992) , 10.1016/S0040-4039(00)60105-3
P. J. Nelson, K. T. Potts, 1,2,4-Triazoles. VI.1 The Synthesis of Some s-Triazolo[4,3-a]pyrazines Journal of Organic Chemistry. ,vol. 27, pp. 3243- 3248 ,(1962) , 10.1021/JO01056A061