Faster FOLFOX: Oxaliplatin Can Be Safely Infused at a Rate of 1 mg/m2/min
作者： Andrea Cercek , Vivian Park , Rona Yaeger , Diane Reidy-Lagunes , Nancy E. Kemeny
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摘要: Purpose:Oxaliplatin at a dose of 85 mg/m2 traditionally has been administered over 120 min in the standard FOLFOX (infusional fluorouracil, leucovorin, and oxaliplatin) regimen. CapeOx (capecitabine plus oxaliplatin), which oxaliplatin is 130 mg/m2, also infused min. Maintenance prolonged infusion time largely based on concern for potential hypersensitivity reaction (HSR) if too quickly.Methods:We first performed retrospective review our institutional experience to assess whether HSR rates were similar by using computerized pharmacy records between January 1, 2011, December 31, 2013. We then instituted new policy infuse all nonresearch doses set rate 1 mg/m2/min (85 given min; 68 min, etc). The incidence HSRs with was actively monitored.Results:Of 2,097 patients who previously received 1,936 dos...
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