TOF-SIMS analysis of adipose tissue from patients with chronic kidney disease
作者： Peter Sjövall , Björn Johansson , Dalila Belazi , Peter Stenvinkel , Bengt Lindholm
DOI: 10.1016/J.APSUSC.2008.05.011
关键词:
摘要: Abstract In this work, time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used for detecting systematic variations in the spatial and compositional distributions of lipids human tissue samples. Freeze-dried sections subcutaneous adipose from six chronic kidney disease (CKD) patients control subjects were analysed by TOF-SIMS using 25 keV Bi 3 + primary ions. Principal component analysis signal intensities different fatty acids, diacylglycerol triacylglycerol ions showed evidence lipid between The main observed difference spectra a concerted variation saturated relative to unsaturated lipids, while acid chain lengths considerably weaker. Furthermore, three samples showing lowest degree saturation came CKD patients, four with highest subjects, indicating that low levels glycerol distribution may be more frequent CKD. Systematic differences several areas.
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