Brainstem and hypothalamic areas activated by tissue hypoxia: Fos-like immunoreactivity induced by carbon monoxide inhalation in the rat.

摘要: Abstract Acute ambient hypoxia interacts with the ventilatory and cardiocirculatory control systems, via concomitant activation of arterial chemoreceptors tissue oxygen-sensing mechanisms. Whether these latter mechanisms may trigger a specific pathway had not yet been elucidated. We addressed this issue, mapping Fos expression in adult conscious rats subjected to elicited by carbon monoxide inhalation, under conditions minimal chemoreceptors. Brief stimuli have delivered (1% inhaled during 5, 10 or 20 min) produce steady hypoxia. Compared normoxia, even briefest led marked neuronal within areas involved control. In brainstem, stimulated exhibited enhanced nucleus solitary tract, area postrema, dorsal motor vagus nerve, ventrolateral medulla, parapyramidal group, raphe pallidus, lateral paragigantocellular nucleus, locus coeruleus, parabrachial area, central gray. hypothalamus, activated neurons were identified at ventral border supramamillary, posterior, dorsomedial nuclei. appeared increasing severity retrotrapezoid tegmental arcuate paraventricular hypothalamic The present data support idea that inputs related might play crucial role patterning physiological response