Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer

摘要: Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, often attributed to late stage at diagnosis and relapse following chemotherapy. HGS a heterogenous disease in that few genes are consistently mutated between patients. Additionally, characterized by genomic instability. For these reasons, personalized approaches may be necessary effective treatment cure. Understanding molecular mechanisms contribute tumor metastasis chemoresistance essential improve survival rates. One favored model stem cell (CSC) model. CSCs cells enhanced self-renewal properties enriched Elimination of this population thought mechanism increase therapeutic response. Therefore, accurate identification populations clinically relevant necessary. While many CSC identifiers (ALDH, OCT4, CD133, side population) have been established, it still not clear which population(s) will beneficial target there critical need characterize reliable markers find their weaknesses make amenable therapy. Many signaling pathways implicated roles initiation maintenance. Therapeutically targeting needed or maintenance an way treating In conclusion, prognosis improved combining phenotyping targeted therapies involved