Bronchial disease in ulcerative colitis.

摘要: Ten patients with ulcerative colitis, all of whom were non-smokers, presented a productive cough. In six, the chest radiography was normal and cough only symptom; three these had minor obstructive ventilatory defect on testing. Four complained exertional dyspnoea both an abnormal radiograph bilateral pulmonary shadows mixed restrictive defect. Bronchial epithelial biopsies from four (two two without shadows) revealed basal reserve cell hyperplasia, basement membrane thickening, submucosal inflammation, changes more usually associated cigarette smoking. Inhaled beclomethasone diproprionate relieved in seven patients. The occurrence airway disease association colitis raises possibility systemic mechanism affecting bronchial colonic epithelium. It does not seem likely that sulphasalazine cause syndrome subjects.