Lower serotonin transporter binding in patients with cervical dystonia is associated with psychiatric symptoms

摘要: Cervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding related with both symptoms jerks/tremor in CD. Serotonergic dopaminergic systems are closely related. As serotonin involved the pathophysiology of psychiatric jerks, we expected an altered serotoninergic system We hypothesized that CD associated reduced (SERT) binding, more specific SERT lower patients and/or compared to those without, controls. balance between DAT can be different phenotypes. In 23 14 healthy controls, diencephalon/midbrain was assessed using [123I]FP-CIT SPECT, a brain-dedicated system. non-specific ratio (binding potential; BPND) main outcome measure. There clear trend towards BPND without (p = 0.05). no correlation dystonia, or anxiety. significant positive extrastriatal striatal but not jerks. have midbrain/diencephalon, while jerks appear unrelated binding.