Pterin transport and metabolism in Leishmania and related trypanosomatid parasites.
作者： Marc Ouellette , Jolyne Drummelsmith , Amal El Fadili , Christoph Kündig , Dave Richard
DOI: 10.1016/S0020-7519(01)00346-0
关键词:
摘要: The folate metabolic pathway has been exploited successfully for the development of antimicrobial and antineoplasic agents. Inhibitors this pathway, however, are not useful against Leishmania other trypanosomatids. Work on mechanism methotrexate resistance in dramatically increased our understanding pterin metabolism organism. cellular functions reduced form folates pterins beginning to be established work led several unexpected findings. Moreover, currently ongoing sequencing efforts trypanosomatid genomes suggesting presence gene products that likely require pterins. A number properties unique these pathways valid worthwhile targets drug development.
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Shyam Sundar Shyam Sundar, DK More, MK Singh, VP Singh, Sashi Sharma Sashi Sharma, Anand Makharia Anand Makharia, PCK Kumar, HW Murray, None, Failure of Pentavalent Antimony in Visceral Leishmaniasis in India: Report from the Center of the Indian Epidemic Clinical Infectious Diseases. ,vol. 31, pp. 1104- 1107 ,(2000) , 10.1086/318121
J. A. Kovacs, C. J. Allegra, J. Beaver, D. Boarman, M. Lewis, J. E. Parrillo, B. Chabner, H. Masur, Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents The Journal of Infectious Diseases. ,vol. 160, pp. 312- 320 ,(1989) , 10.1093/INFDIS/160.2.312
David J. Hammond, Winston E. Gutteridge, Purine and pyrimidine metabolism in the trypanosomatidae Molecular and Biochemical Parasitology. ,vol. 13, pp. 243- 261 ,(1984) , 10.1016/0166-6851(84)90117-8
David A. Scott, Graham H. Coombs, Barbara E. Sanderson, Folate utilisation by Leishmania species and the identification of intracellular derivatives and folate-metabolising enzymes Molecular and Biochemical Parasitology. ,vol. 23, pp. 139- 149 ,(1987) , 10.1016/0166-6851(87)90149-6
Paul F. Fitzpatrick, Tetrahydropterin-dependent amino acid hydroxylases. Annual Review of Biochemistry. ,vol. 68, pp. 355- 381 ,(1999) , 10.1146/ANNUREV.BIOCHEM.68.1.355
Richard J.S. Burchmore, Michael P. Barrett, Life in vacuoles--nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology. ,vol. 31, pp. 1311- 1320 ,(2001) , 10.1016/S0020-7519(01)00259-4
Jingyu Wang, Éric Leblanc, Chi-Feng Chang, Barbara Papadopoulou, Tom Bray, John M. Whiteley, Sheng-Xiang Lin, Marc Ouellette, Pterin and Folate Reduction by theLeishmania tarentolaeH Locus Short-Chain Dehydrogenase/Reductase PTR1 Archives of Biochemistry and Biophysics. ,vol. 342, pp. 197- 202 ,(1997) , 10.1006/ABBI.1997.0126
Daniel V. Santi, Pat Nolah, Barry Shane, Folylpolyglutamates in Leishmania major Biochemical and Biophysical Research Communications. ,vol. 146, pp. 1089- 1092 ,(1987) , 10.1016/0006-291X(87)90759-5
Birgit W. Wetterauer, Klaus Salger, Aberrant folate response and premature development in a mutant of Dictyostelium discoideum. Differentiation. ,vol. 66, pp. 197- 207 ,(2000) , 10.1046/J.1432-0436.2000.660406.X
K. I. Varughese, N. H. Xuong, P. M. Kiefer, D. A. Matthews, J. M. Whiteley, Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 5582- 5586 ,(1994) , 10.1073/PNAS.91.12.5582