Emerging roles for histone deacetylases in age-related muscle atrophy.
作者： Michael E. Walsh , Holly Van Remmen
DOI: 10.3233/NHA-160005
关键词:
摘要: BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is associated with weakness, frailty, and the loss of independence in older adults. The mechanisms contributing to sarcopenia are not totally understood, but fiber due apoptosis, reduced stimulation anabolic pathways, activation catabolic denervation, altered metabolism have been observed from old rodents humans. OBJECTIVE: Recently, histone deacetylases (HDACs) implicated dysfunction muscular dystrophy, disuse, HDACs play key roles regulating skeletal muscle. In this review, we will discuss role potential HDAC inhibitors for treatment sarcopenia. CONCLUSIONS: Several isoforms targets intervention Inhibition HDAC1 prevents nutrient deprivation. HDAC3 regulates may inhibit oxidative aging. HDAC4 HDAC5 already use clinic, there promise targeting
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