Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells

摘要: Recent evidence indicates that the genetic alterations of multistage process malignant transformation appear to activate tumor neovascularization by altering balance between stimulators and inhibitors angiogenesis. In present study, we have attempted define effect enhanced MYCN oncogene expression on profile endothelial cell growth modulators in neuroblastoma cells. We report here conditioned medium human cells with normal contains three proliferation, which be novel proteins as judged their physicochemical, immunological biological properties. All are diminished or become undetectable upon experimental increase expression. Our results suggest alters angiogenic down-regulating but leaving unaffected. These data shed light molecular mechanisms linking changes initiation Moreover, our observations might explain poor prognosis neuroblastomas following amplification through angiogenesis subsequent spread.