Negative and positive predictive value of a whole-blood interferon-γ release assay for developing active tuberculosis: an update.
作者： Roland Diel , Robert Loddenkemper , Stefan Niemann , Karen Meywald-Walter , Albert Nienhaus
DOI: 10.1164/RCCM.201006-0974OC
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摘要: Rationale: Only limited data are available on the predictive value of interferon-γ release assays for progression from latent tuberculosis infection to active (TB).Objectives: To build our initial study comparing QuantiFERON-TB Gold in-tube assay (QFT) with tuberculin skin test (TST) in close contacts patients TB and evaluating up 4 years.Methods: A cohort smear-positive index cases established between May 2005 April 2008 was tested QFT TST. Through 2010, progressors were consecutively recorded.Measurements Main Results: Of 1,414 (141 children), 1,033 still resident Hamburg at end period, results both tests 954. QFT, but not TST, associated exposure time (P < 0.0001). For 198 954 (20.8%) positive; 63.3% (604) TST positive greater than 5 mm 25.4% 10 mm. Nine hundred ...
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