[Cost-effectiveness analysis of universal screening for thyroid disease in pregnant women in Spain].

摘要: Objective To assess the cost-effectiveness of universal screening for thyroid disease in pregnant women Spain as compared to high risk and no screening. Methodology A decision-analytic model comparing incremental cost per quality-adjusted life year (QALY) versus was used pregnancy postpartum period. Probabilities from randomized controlled trials were considered adverse obstetrical outcomes. Markov lifetime period after first account development overt hypothyroidism. The main assumptions use resources assessed by local clinical experts. analysis direct healthcare costs only. Results Universal gained .011 QALYs over .014 QALYS Total patient €5,786 screening, €5,791 €5,781 dominant risk-based a very cost-effective alternative Use instead would result €2,653,854 annual savings Spanish National Health System. Conclusions trimester is (incremental ratio €374 QALY). Moreover, it allows diagnosing treating cases subclinical hypothyroidism that may not be detected when only high-risk are screened.