An epidemiologic study of smoking and primary infertility in women

摘要: Objective To determine the relationship between cigarette smoking and primary female infertility. Design Retrospective, case-control study. Setting Population-based randomly selected from eight geographic areas in United States. Participants Women, 20 to 54 years of age, who were serve as control group Cancer Steroid Hormone Study used for this Within group, there 483 women classified having experienced infertility 2,231 eligible controls. Primary infertility, defined 24 consecutive months unprotected intercourse without conception, was documented a calendar each woman's reproductive contraceptive history. Results Smoking one pack cigarettes per day (odds ratio=1.36) starting smoke before 18 age ratio=1.30) significantly associated with increased risk Life table proportional hazards analysis indicated that did not increase time required conceive among infertile women. Conclusions Number smoked when woman began contributed It is reasonable, therefore, recommend stop they are attempting become pregnant.