Dose response relationships during perinatal lead administration in the rat: a model for the study of lead effects on brain development.
作者： Neil G. Carmichael , Christopher Winder , Paul D. Lewis
DOI: 10.1016/0300-483X(81)90122-0
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摘要: Abstract Pregnant rats were dosed with 300, 600, 1000, 2000, 3000 or 4000 ppm inorganic lead through their drinking water during pregnancy and lactation until 21 days post partrum. An effect on live litter size was noted at the higher doses as an increased tendency for sperm positive females to fail produce a litter. Dose related responses seen in offspring brain weight, body length blood birth age days. In neonates from dose groups above 1000 Pb these 3 indices of growth indicated that there nutrition. The 300 ppm, 600 showed no significant effects weight only slight weight. These low gave average values 39.8 μg/100 blood, 54.6 ml 85.4 respectively 21-day old neonates. correspond children so called “subclinical poisoning” we suggest use this regime model investigate development nervous system.
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