Hypertension in terminal renal failure. Observations pre and post bilateral nephrectomy.

摘要: Abstract The clinical course of 16 patients, 13 hypertensive and 3 normotensive, with terminal renal failure undergoing periodic hemodialysis has been observed before after bilateral nephrectomy. Eight patients on dialysis for 3.5–18 months developed features accelerated hypertension resistant to multiple drug therapy ultrafiltration dialysis. Serum renin activity was markedly increased in 6 within normal range 2. Hemodynamic studies performed 5 activity, revealed expanded plasma volume, near cardiac index peripheral resistance. Following nephrectomy control hypertension, blood pressure decreased significantly all 8 patients. During 1.5–21.5 anephric state, 2 became were moderately hypertensive. However, readily controllable 4 these by alone. other required reduced amounts methyldopa also. Post nephrectomy, output greater resistance less than pre Five 4–16 had which 1. showed Bilateral electively preparation possible transplantation. 3.5 48 normotensive 1 remained volume significantly, while unchanged. Three 1–5 values serum activity. After elective transplantation, normotensive. Assays at varying intervals post Renin half-time disappearance rate ranged from 140 360 min still present the sera a female male, more yr respectively, This abolished adding human antirenin incubation.