Pressor response to angiotensin II in hypertension. Correlation with plasma renin activity and response to norepinephrine and metaraminol.

摘要: Abstract The pressor response to angiotensin II infused intravenously was studied in 8 normal subjects and 44 patients with primary secondary hypertension. mean dose of required increase diastolic blood pressure by 20 mm. Hg significantly lower 24 essential hypertension than control 11 renovascular Mean plasma renin activity peripheral venous similar higher directly correlated activity. However, norrnotensive values exhibited markedly different sensitivity II. Further, the norepinephrine metaraminol paralleled that both patient groups individual cases. results suggest hypertensive is related not only level circulating endogenous but also nonspecific hyperreactivity hyporeactivity