Cerebrovascular Regulation in Preganglionic and Postganglionic Autonomic Insufficiency

摘要: Cerebral blood flow was measured in four subjects with chronic idiopathic autonomic insufficiency using 85Kr inhalation, cerebral A-V samples for scintillation counting, and O2 content determination. Blood pressure varied by up or down tilting L-norepinephrine infusion. In three patients typical Shy-Drager syndrome preganglionic denervation, CBF regulation to PaCOCO2 change intact. a fourth patient postganglionic autoregulation absent changes but preserved normally increases decreases CMRO2, at rest were normal (52.6 cc 3.1 cc). Hyperventilation 34.3 mm failed restore increased pressure. The results imply functional role fibers autoregulation.