High Levels of Stromal Hyaluronan Predict Poor Disease Outcome in Epithelial Ovarian Cancer

摘要: Several malignant tumors accumulate hyaluronan, a matrix component suggested to promote cancer cell migration and growth. To explore the potential clinical importance of this concept, we assessed hyaluronan levels in epithelial ovarian cancer. A biotinylated affinity probe specific for was prepared applied histological sections 309 cancers 45 matched metastatic lesions. The staining scored according percentage area strong signal total peri- intratumoral stroma as low ( 75%). Low, moderate, high stromal were observed 95, 116, 98 carcinomas, respectively. level significantly associated with poor differentiation, serous type, advanced stage, large primary residual tumor, whereas it not correlated CD44 expression on cells. 5-year outlook disease deteriorated increasing both overall (45% versus 39% 26%; P = 0.002) recurrence-free (66% 56% 40%; 0.008) survival. High more frequent lesions than (z -3.9; 0.0001). In Cox's multivariate analyses, an independent prognostic factor all patients, well stage-specific subgroups. These results suggest that accumulation may be powerful enhancer tumor progression and, such, provides novel, marker target therapy.