Drug Elimination and Apparent Volume of Distribution in Multicompartment Systems

摘要: Abstract A relationship between drug distribution and elimination in multicompartment systems has been demonstrated, which suggests that under certain conditions a decrease the rate constant ( k el ) results significant apparent volume of distribution. The mathematical relationships are consistent with experimental findings as to effect probenecid or renal failure on implications change distribution, patients impaired function other resulting reduced elimination, respect "dose"‐response relationships, estimation bioavailability absorption rate, biologic half‐life impairment processes, use creatinine clearance measurements guide design dosage regimens disease considered.