Concise Review: Targeting Cancer Stem Cells Using Immunologic Approaches

作者: Qin Pan , Qiao Li , Shuang Liu , Ning Ning , Xiaolian Zhang

DOI: 10.1002/STEM.2039

关键词:

摘要: Cancer stem cells (CSCs) represent a small subset of tumor which have the ability to self-renew and generate diverse that comprise bulk. They are responsible for local recurrence distant metastasis. However, they resistant conventional radiotherapy chemotherapy. Novel immunotherapeutic strategies specifically target CSCs may improve efficacy cancer therapy. To immunologically CSC phenotypes, innate immune responses been reported using Natural killer γδ T cells. specifically, in vitro CSC-primed successfully generated shown targeting vivo after adoptive transfer. Recently, CSC-based dendritic cell vaccine has demonstrated significant induction anti-CSC immunity both immunocompetent hosts as evident by reactivity vaccine-primed antibodies In addition, identification specific antigens or genetic alterations provide more targets immunotherapy. ALDH, CD44, CD133, HER2 served markers isolate from number types animal models human tumors. might serve useful Finally, since regulated interactions with niche, these additional Targeting microenvironment, such interrupting cell, example, myeloid-derived suppressor cells, cytokines, IL-6 IL-8, well checkpoint (PD1/PDL1, etc.) novel enhance immunological CSCs.

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