Diagnostic significance of allelic imbalance in cancer.

摘要: Allelic imbalance (AI), a deviation from the normal 1:1 ratio of maternal and paternal alleles, occurs in virtually all solid blood-borne malignancies. The frequency spectrum AI tumor cell reflects karyotypic complexity cancer genome. Hence, many investigations have assessed extent to analyze differences between tissues variety different organs. In this review, authors describe established emerging technologies used assess human tissues, their application diagnosis cancer. four major methods be reviewed represent powerful widely tools for identification allelic imbalances accompanying initiation progression. These are fluorescent situ hybridization, comparative genomic single nucleotide polymorphism arrays use microsatellite markers. For each method, provide brief description approach elaborate on specific studies...