Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact.
作者： Thomas Ried , Torsten Liersch , Heinz Becker , B. Michael Ghadimi , Marian Grade
DOI: 10.1155/2006/173815
关键词: Fluorescence in situ hybridization 、 Cancer research 、 Comparative genomic hybridization 、 Cancer 、 Colorectal carcinogenesis 、 Karyotype 、 Molecular cytogenetics 、 Bioinformatics 、 Colorectal cancer 、 Biology 、 Human genome
摘要: Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence situ hybridization (FISH) based techniques such as comparative genomic (CGH) and spectral karyotyping (SKY) revealed that carcinomas are characterized by specific pattern chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides background on the functional relevance for progression discusses their potential clinical impact.
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