Identification of Novel Prognosticators of Outcome in Squamous Cell Carcinoma of the Head and Neck
作者： Volkert B. Wreesmann , Weiji Shi , Howard T. Thaler , Ashok Poluri , Dennis H. Kraus
关键词:
摘要: Purpose The goal of this study was to identify chromosomal aberrations associated with poor outcome in patients head and neck squamous cell carcinoma (HNSCC). Patients Methods We assessed the global genomic composition 82 HNSCCs from previously untreated comparative hybridization (CGH). CGH data were subcategorized into individual cytogenetic bands. Only occurring more than 5% cases analyzed, redundancies eliminated. Each aberration submitted univariate analysis assess its relationship disease-specific survival (DSS). used Monte Carlo simulations (MCS) adjust P values for log-rank approximate χ2 statistics each abnormality further applied Hochberg-Benjamini procedure multiple testing large number abnormalities. then abnormalities whose tests resulted an adjusted value less .15 together significant demographic/clini...
sci-hub.se 参考文章(39)
Stanislas du Manoir, David C. Ward, Paul Crotty, José Costa, Chris Howe, Michael R. Speicher, Comparative Genomic Hybridization Detects Novel Deletions and Amplifications in Head and Neck Squamous Cell Carcinomas Cancer Research. ,vol. 55, pp. 1010- 1013 ,(1995)
Volker Jahnke, Günter Wolf, Sven Schmidt, Simone Petersen, Ulrike Bockmühl, Manfred Dietel, Iver Petersen, Patterns of Chromosomal Alterations in Metastasizing and Nonmetastasizing Primary Head and Neck Carcinomas Cancer Research. ,vol. 57, pp. 5213- 5216 ,(1997)
Bhuvanesh Singh, Volkert B Wreesmann, David Pfister, Ashok Poluri, Ashok R Shaha, Dennis Kraus, Jatin P Shah, Pulivarthi H Rao, Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposure BMC Genetics. ,vol. 3, pp. 22- 22 ,(2002) , 10.1186/1471-2156-3-22
Ashok R. Shaha, Pornchai O-charoenrat, Cherry L. Estilo, Joseph M. Huryn, Ivan Ngai, Richard J. Wong, David G. Pfister, Su Dao, Dennis H. Kraus, Jatin P. Shah, Pabbathi G. Reddy, Bhuvanesh Singh, Snehal G. Patel, Jay O. Boyle, Ian M. Zlotolow, The role of novel oncogenes squamous cell carcinoma-related oncogene and Phosphatidylinositol 3-kinase p110α in squamous cell carcinoma of the oral tongue Clinical Cancer Research. ,vol. 9, pp. 2300- 2306 ,(2003)
Ashok R. Shaha, Jatin P. Shah, Archontoula Stoffel, Pulivarthi H. Rao, Bhuvanesh Singh, Peter G. Sacks, Swarna K. Gogineni, Molecular Cytogenetic Characterization of Head and Neck Squamous Cell Carcinoma and Refinement of 3q Amplification Cancer Research. ,vol. 61, pp. 4506- 4513 ,(2001)
S Ozawa, M Kitajima, M Terada, N Ando, H Shinozaki, M Ueda, H Tsuruta, Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information. Clinical Cancer Research. ,vol. 2, pp. 1155- 1161 ,(1996)
Thomas J. Belbin, Michael B. Prystowsky, Ilana Barber, Richard Smith, Geoffrey Childs, Bruce Wenig, Bhuvanesh Singh, Nicholas Socci, Molecular Classification of Head and Neck Squamous Cell Carcinoma Using cDNA Microarrays Cancer Research. ,vol. 62, pp. 1184- 1190 ,(2002)
A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641
Thomas Belbin, Bhuvanesh Singh, Ilana Barber, Bruce Wenig, Richard Smith, Mike Prystowsky, Geoffrey Childs, Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays Nature Genetics. ,vol. 27, pp. 42- 43 ,(2001) , 10.1038/87004
Sharon Brookes, G. Alistair Lammie, Ed Schuuring, Carla De Boer, Rob Michalides, Clive Dickson, Gordon Peters, Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. Genes, Chromosomes and Cancer. ,vol. 6, pp. 222- 231 ,(1993) , 10.1002/GCC.2870060406