Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients

摘要: Background: Colorectal cancer (CRC) is one of the most common causes cancer-related deaths in Western world, and despite fact that metastases are usually ultimate cause deaths, knowledge genetics advanced stages this disease limited. In order to identify potential genetic abnormalities underlying development local distant CRC patients, we have, by comparative genomic hybridization, compared DNA copy number profiles 10 primary carcinomas, 14 recurrences, 7 peritoneal carcinomatoses, 42 liver from 61 patients. Results: The median aberrations among was 10, 6, 13, 14, respectively. Several imbalances, such as gains 7, 8q, 13q, 20, losses 4q, 8p, 17p, 18, were all groups. contrast, 5p 12p more carcinomatoses than other disease. With hierarchical cluster analysis, could be divided into two main subgroups according clusters chromosome changes. Conclusions: Each stage progression characterized a particular profile, both genetically complex recurrences carcinomas. This first genome profiling seem particularly important for spread cells within cavity.