Copy number alterations and allelic ratio in relation to recurrence of rectal cancer.

摘要: Background In rectal cancer, total mesorectal excision surgery combined with preoperative (chemo)radiotherapy reduces local recurrence rates but does not improve overall patient survival, a result that may be due to the harmful side effects and/or co-morbidity of treatment. New biomarkers are needed facilitate identification cancer patients at high risk for recurrent disease. This would allow restricted high-risk patients, thereby reducing overtreatment and allowing personalized treatment protocols. We analyzed genome-wide DNA copy number (CN) allelic alterations in 112 tumors from preoperatively untreated patients. Sixty-six distant disease were compared matched controls without recurrence. Results validated second cohort 95 Additionally, we performed meta-analysis included 42 studies reporting on CN colorectal results our own data.