Comparative Genomic in Situ Hybridization of Colon Carcinomas with Replication Error
作者： Tina Bocker , Ferdinand Hofstädter , Jürgen Schlegel , Josef Rüschoff , Harry Scherthan
DOI:
关键词: In situ hybridization 、 Pathogenesis 、 Replication Error 、 Carcinoma 、 Genetics 、 In situ 、 Cancer research 、 Microsatellite 、 Rectum 、 Biology 、 Microsatellite instability
摘要: The aim of the present study was to detect complex genetic alterations in colorectal carcinomas with and without microsatellite instability (MIN) by comparative genomic situ hybridization. MIN due replication errors is hallmark hereditary nonpolyposis colon cancer. None 6 MIN-positive tumors showed amplifications, only 2 displayed deletions one chromosomal segment each. In contrast, different gains losses were observed 11 12 MIN-negative carcinomas. most frequent affected chromosomes 7, 13, 20q, whereas on 17, 18, 9p. These results demonstrate mechanisms subgroups may, therefore, support hypothesis etiologies MIN.
aacrjournals.org参考文章(18)
Eric R. Fearon, Bert Vogelstein, A genetic model for colorectal tumorigenesis Cell. ,vol. 61, pp. 759- 767 ,(1990) , 10.1016/0092-8674(90)90186-I
J. Schlegel, T. Bocker, F. Hofst�dter, J. R�schoff, H. Zirngabel, Detection of microsatellite instability in human colorectal carcinomas using a non-radioactive PCR-based screening technique Virchows Archiv. ,vol. 426, pp. 223- 227 ,(1995) , 10.1007/BF00191358
J. R�schoff, T. Bocker, J. Schlegel, G. Stumm, F. Hofstaedter, Microsatellite instability: new aspects in the carcinogenesis of colorectal carcinoma Virchows Archiv. ,vol. 426, pp. 215- 222 ,(1995) , 10.1007/BF00191357
Georgia Bardi, Bertil Johansson, Nikos Pandis, Elisabeth Bak-Jensen, Charlotte Örndal, Sverre Heim, Nils Mandahl, Ake Andrén-Sandberg, Felix Mitelman, Cytogenetic aberrations in colorectal adenocarcinomas and their correlation with clinicopathologic features Cancer. ,vol. 71, pp. 306- 314 ,(1993) , 10.1002/1097-0142(19930115)71:2<306::AID-CNCR2820710207>3.0.CO;2-C
Lauri A Aaltonen, Päivi Peltomäki, Fredrick S Leach, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Steven M Powell, Jin Jen, Stanley R Hamilton, Gloria M Petersen, Kenneth W Kinzler, Bert Vogelstein, Albert De La Chapelle, Clues to the pathogenesis of familial colorectal cancer Science. ,vol. 260, pp. 812- 816 ,(1993) , 10.1126/SCIENCE.8484121
Vladimir Lazar, Sophie Grandjouan, Caroline Bognel, Daniel Couturier, Philippe Rougier, Dominique Bellet, Brigitte Bressac-de Paillerets, Vladimir Lazar, Sophie Grandjouan, Caroline Bognel, Daniel Couturier, Philippe Rougier, Dominique Bellet, Brigitte Bressac-de Paillerets, Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients Human Molecular Genetics. ,vol. 3, pp. 2257- 2260 ,(1994) , 10.1093/HMG/3.12.2257
Fredrick S. Leach, Nicholas C. Nicolaides, Nickolas Papadopoulos, Bo Liu, Jin Jen, Ramon Parsons, Päivi Peltomäki, Pertti Sistonen, Lauri A. Aaltonen, Minna Nyström-Lahti, X.-Y. Guan, Ji Zhang, Paul S. Meltzer, Jing-Wei Yu, Fa-Ten Kao, David J. Chen, Karen M. Cerosaletti, R.E.Keith Fournier, Sean Todd, Tracey Lewis, Robin J. Leach, Susan L. Naylor, Jean Weissenbach, Jukka-Pekka Mecklin, Heikki Järvinen, Gloria M. Petersen, Stanley R. Hamilton, Jane Green, Jeremy Jass, Patrice Watson, Henry T. Lynch, Jeffrey M. Trent, Albert de la Chapelle, Kenneth W. Kinzler, Bert Vogelstein, Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer Cell. ,vol. 75, pp. 1215- 1225 ,(1993) , 10.1016/0092-8674(93)90330-S
Gunn Iren Meling, Minna Nystrom-Lahti, Ragnhild A. Lothe, Lauri A. Aaltonen, Torleiv O. Rognum, Tone I. Andersen, Paivi Peltomaki, Albert de la Chapelle, Sophie D. Fossa, Lea Pylkkanen, Anne Lise B rresen, Fr ydis Langmark, Anton Br gger, Pal Mller, Tor Haldorsen, Ketil Heimdal, Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Research. ,vol. 53, pp. 5849- 5852 ,(1993)
Stanislas du Manoir, Michael R. Speicher, Stefan Joos, Evelin Schröck, Susanne Popp, Hartmut Döhner, Gyula Kovacs, Michel Robert-Nicoud, Peter Lichter, Thomas Cremer, Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization Human Genetics. ,vol. 90, pp. 590- 610 ,(1993) , 10.1007/BF00202476
Stefan Joos, Harry Scherthan, MichaelR. Speicher, J�rgen Schlegel, Thomas Cremer, Peter Lichter, Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe Human Genetics. ,vol. 90, pp. 584- 589 ,(1993) , 10.1007/BF00202475