Chromosomal aberrations in colorectal cancers and liver metastases analyzed by comparative genomic hybridization.
作者： Hideki Aragane , Chouhei Sakakura , Masayoshi Nakanishi , Rie Yasuoka , Yoshifumi Fujita
DOI: 10.1002/IJC.1522
关键词:
摘要: Comparative genomic hybridization (CGH) was used to screen for changes in the number of DNA sequence copies 30 primary colorectal cancers and 16 liver metastases, identify regions that contain genes important development progression cancer. In cancer, we found frequent gains at 7p21 (36.7%), 7q31-36 (30%), 8q23-24 (43.0%), 12p 14q24-32 (33.3%), 16p (40.0%), 20p 20q (63.3%) 21q (36.3%), while loss often noted 18q12-23 (36.7%). metastatic tumors, there were significantly more losses sequences than with (found 62.5% recurrences vs. 43.0% tumors), 15q21-26 (37.5% 20.0%), 19p (43.8% 20.0%) (81.3% 63.3%) (50.0% 36.7%). The pattern genetic seen 18q12-23, suggests We investigated a clinical follow-up study all patients examined by CGH directed our attention consisting 8q 20q. incidence metastases higher cancer these changes. Gains might be useful high risk developing metastases.
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