Comparative study of proteome between primary cancer and hepatic metastatic tumor in colorectal cancer
作者： Bo Yu
关键词:
摘要: AIM: To identify the differential proteins associated with colorectal cancer genesis and hepatic metastasis. METHODS: Hydrophobic protein samples were extracted from normal mucosa, primary lesion metastatic foci of cancer. With two-dimensional electrophoresis image analysis, differentially expressed spots detected, identified by matrix assisted laser desorption/ionization-time flight-mass spectrometry peptide mass fingerprint analysis. RESULTS: Significant alterations in number expression levels discovered foci, a was lost 25-40 ku, but increased 14-21 compared mucosa. Nine identified. Three metastasis, recognized as calmodulin, ribonuclease 6 precursor mannosidase-α. Proapolipoprotein progressively mucosa to metastasis. The beta-globin found tumor, lesion. Cdc 42, GTP-binding protein, C4 cancer, M7 M9 metastasis had less homology database. CONCLUSION: Variations hydrophobic initiation are significant can be observed electrophoresis. mannosidase-α is proapolipoprotein enhanced which 42 abnormally Protein C4, may
sci-hub.st 参考文章(31)
Xing-Guo Li, Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer World Journal of Gastroenterology. ,vol. 7, pp. 551- 554 ,(2001) , 10.3748/WJG.V7.I4.551
Louis-Georges Guy, Qi Mei, Andrew C. Perkins, Stuart H. Orkin, Lee Wall, Erythroid Krüppel-Like Factor Is Essential for β-Globin Gene Expression Even in Absence of Gene Competition, But Is Not Sufficient to Induce the Switch From γ-Globin to β-Globin Gene Expression Blood. ,vol. 91, pp. 2259- 2263 ,(1998) , 10.1182/BLOOD.V91.7.2259
Donald E. Henson, Sudhir Srivastava, Mukesh Verma, Biomarkers for Early Detection of Colon Cancer Clinical Cancer Research. ,vol. 7, pp. 1118- 1126 ,(2001)
Shin-ichi Seto, Hisashi Onodera, Toshimi Kaido, Akira Yoshikawa, Shun-ichi Ishigami, Shigeki Arii, Masayuki Imamura, Tissue factor expression in human colorectal carcinoma: correlation with hepatic metastasis and impact on prognosis. Cancer. ,vol. 88, pp. 295- 301 ,(2000) , 10.1002/(SICI)1097-0142(20000115)88:2<295::AID-CNCR8>3.0.CO;2-U
Fatiha Nassir, Denise K. Bonen, Nicholas O. Davidson, Apolipoprotein(a) Synthesis and Secretion from Hepatoma Cells Is Coupled to Triglyceride Synthesis and Secretion Journal of Biological Chemistry. ,vol. 273, pp. 17793- 17800 ,(1998) , 10.1074/JBC.273.28.17793
Shine Tu, Richard A Cerione, None, Cdc42 Is a Substrate for Caspases and Influences Fas-induced Apoptosis Journal of Biological Chemistry. ,vol. 276, pp. 19656- 19663 ,(2001) , 10.1074/JBC.M009838200
Anne Filipe, Qiliang Li, Sophie Deveaux, Isabelle Godin, Paul‐Henri Roméo, George Stamatoyannopoulos, Vincent Mignotte, Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. The EMBO Journal. ,vol. 18, pp. 687- 697 ,(1999) , 10.1093/EMBOJ/18.3.687
Hideki Aragane, Chouhei Sakakura, Masayoshi Nakanishi, Rie Yasuoka, Yoshifumi Fujita, Hiroki Taniguchi, Akeo Hagiwara, Toshiharu Yamaguchi, Tatsuo Abe, Johji Inazawa, Hisakazu Yamagishi, Chromosomal aberrations in colorectal cancers and liver metastases analyzed by comparative genomic hybridization. International Journal of Cancer. ,vol. 94, pp. 623- 629 ,(2001) , 10.1002/IJC.1522
Satoshi Nakamura, Shohachi Suzuki, Shozo Baba, Resection of Liver Metastases of Colorectal Carcinoma World Journal of Surgery. ,vol. 21, pp. 741- 747 ,(1997) , 10.1007/S002689900300
M Wijgerde, J Gribnau, T Trimborn, B Nuez, S Philipsen, F Grosveld, P Fraser, The role of EKLF in human beta-globin gene competition. Genes & Development. ,vol. 10, pp. 2894- 2902 ,(1996) , 10.1101/GAD.10.22.2894