The Evolving Role of Microsampling in Therapeutic Drug Monitoring of Monoclonal Antibodies in Inflammatory Diseases.
作者： Tomaž Vovk , Iztok Grabnar , Jurij Zdovc , Panagiotis-Dimitrios Mingas
DOI: 10.3390/MOLECULES26061787
关键词:
摘要: Monoclonal antibodies (mAbs) have been extensively developed over the past few years, for treatment of various inflammatory diseases. They are large molecules characterized by complex pharmacokinetic and pharmacodynamic properties. Therapeutic drug monitoring (TDM) is routinely implemented in therapy with mAbs, to monitor patients’ response further guide dose adjustments. Serum has matrix choice TDM mAbs its sampling requires visit patients laboratories that not always easily accessible. Therefore, dried blood spots (DBS) microsampling techniques suggested as an alternative. DBS a technique which capillary deposited on special filter paper. It relatively simple procedure, can perform home-sampling. The convenience it offers enabled use quantification small-molecule drugs, whilst recent studies aimed develop methods will facilitate mAbs. Nevertheless, hematocrit still remains obstacle hinders more widespread implementation clinical practice. introduction novel analytical contemporary devices be considered steppingstone attempts made addressing this issue.
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