Oncolytic Viruses and the Eradication of Drug-Resistant Tumor Cells

摘要: The main objective of oncolytic virus therapy described so far is the successful control or elimination tumor. Here, we describe an alternative goal in case fails to eradicate can be used “pre-treat” cancer and specifically drive drug-resistant mutants extinct. This prepares ground for subsequent drug treatment, which then successfully tumor into remission without resistance-induced failure. key this concept that many suffer a fitness cost compared susceptible cells absence drug. When introduced before drug, less fit resistant share enemy, virus, with fitter cells. In case, apparent competition occur, lead exclusion inferior type even though coexistence occurs virus. Therefore, competition, mediated by mutant extinct would otherwise present prepare therapy.