Sterile abscesses in glioma patients treated by intraparenchymal injection of lymphokine-activated killer cells and recombinant interleukin-2: case reports.

摘要: Earlier, we conducted Phase I clinical trials to determine any acute toxicity of adoptive immunotherapy with intralesional injections autologous lymphocytes expressing lymphokine-activated killer (LAK) activity and recombinant interleukin-2 (rIL-2) in patients malignant glioma. Within six weeks craniotomy injection LAK cells plus rIL-2, 3 29 demonstrated a decline status evidence on computed tomographic magnetic resonance imaging scans edema mass unknown character at the site previous surgery immunotherapy. Craniotomy was performed remove tissue reduce intracranial pressure. Microscopic examination excised material indicated no new tumor growth within resected mass, but rather that had histological characteristics chronic sterile abscess including necrosis, fibrosis, influx inflammatory cells. Factors may have contributed this reaction were age, Karnofsky score, extent excision, immune status. All also been treated greater than average numbers rIL-2 activated significant vitro activity. The results suggest whose is good who are not immunosuppressed by corticosteroids, dose-limiting intraparenchymal for glioma be related total, absolute number injected, develops over time manifested development abscess.