Periventricular Leukomalacia in Adults: Clinicopathological Study of Four Cases

摘要: • The pathological findings in four patients with courses characterized by acute coma and respiratory insufficiency occurring obscure circumstances are presented. Carbon monoxide intoxication was excluded. After an early partial recovery from coma, the remained a persistent vegetative state, tetrapyramidal syndrome. Pathologic changes consisted of infarction demyelination periventricular white matter, associated necrotic foci basal ganglia some cases. We propose that prolonged hypoxia ischemia produce "no reflow" phenomenon causing brain edema (more pronounced matter); this resulted infarctions matter arterial end border zones.