Senile Dementia of the Binswanger Type

摘要: Computed tomography and magnetic resonance imaging in the elderly have demonstrated common occurrence of deep white-matter lesions aging brain. These radiologic (leukoaraiosis) may represent an early marker dementia. At autopsy, ischemic periventricular leukoencephalopathy (Binswanger's disease) has been found most cases. The clinical spectrum Binswanger's disease appears to range from asymptomatic dementia with focal deficits, frontal signs, pseudobulbar palsy, gait difficulties, urinary incontinence. name senile Binswanger type (SDBT) is proposed for this poorly recognized, vascular form subcortical SDBT probably results cortical disconnection likely caused by hypoperfusion. In contrast, multi-infarct correlated multiple large small strokes that cause a loss over 50 100 mL brain volume. white matter watershed area irrigated long, penetrating medullary arteries. Risk factors are small-artery diseases, such as hypertension amyloid angiopathy, impaired autoregulation cerebral blood flow elderly, hypoperfusion due cardiac failure, arrhythmias, hypotension. be potentially preventable treatable